hopefully final commit
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\section{Introduction}\label{sec:introduction}
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Reproductive health and fertility prediction are of increasing importance at both the individual and societal level.
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Globally, maternal age at first pregnancy continues to rise, driven by social and economic factors~\cite{sauer_reproduction_2015}.
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This trend increases the prevalence of cycle irregularity and subfertility, amplifying the need for reliable,
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non-invasive methods of fertility tracking.
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At the same time, many individuals seek alternatives to hormonal contraception, fueling the growth of so-called
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\emph{FemTech} applications for digital health.
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Accurate fertility prediction thus carries implications not only for individual reproductive autonomy,
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but also for public health, demographic trends, and the development of safe, data-driven fertility support tools.
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While textbooks often describe a menstrual cycle as lasting 28 to 30 days with ovulation around day 14~\cite{owen_physiology_nodate},
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such regularity is the exception rather than the rule~\cite{munster_length_1992, bull_real-world_2019}.
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@@ -31,9 +39,14 @@ others suggest its predictive value for ovulation~\cite{sato_novel_2024, royston
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However, most existing studies rely on small, idealized datasets that exclude cycles with irregular lengths or late ovulation.
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While such restrictions simplify the prediction task and yield high accuracy, they give a misleading impression of real-world model performance.
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It is thus not yet fully clear whether temperature can reliably be used as a predictive marker for ovulation or fertility.
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Additionally, other studies have focused on peripheral temperature measurements of skin or in-ear temperature,
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which are subject to many sources of noise that can significantly affect the quality of the resulting predictions.
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To date, no study has systematically evaluated machine learning architectures on a large-scale,
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high-resolution dataset of intravaginal core body temperature across both regular and irregular cycles.
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Such an evaluation is crucial to determine whether temperature-based models can provide robust predictions
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under real-world variability, rather than only on highly regular, curated subsets of data.
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Intravaginal temperature reflects true core body temperature and offers higher resolution and stability,
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as it is largely unaffected by external circumstances.
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This allows for more reliable detection of subtle thermal shifts associated with ovulation, especially in irregular cycles.
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@@ -44,8 +57,10 @@ an intravaginal wearable device that continuously measures core body temperature
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The objective is to develop a machine learning model that performs reliably across diverse cycle types, including irregular ones.
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To this end, we compare a set of time series-based machine learning architectures and evaluate their performance for
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NFP and contraception.
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Finally, we demonstrate that high predictive accuracy on highly regular, curated datasets, as commonly reported in prior work,
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may overestimate real-world applicability, since such datasets tend to favor even simple, rule-based approaches.
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This thesis addresses this gap by providing the first large-scale, systematic comparison of LSTM and
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Transformer architectures on high-resolution intravaginal temperature data.
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It evaluates robustness across diverse cycle types and demonstrates their practical relevance for contraception and NFP\@.
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The main research objective is to evaluate the fundamental feasibility of predicting fertility and
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ovulation from body temperature data using machine learning,
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@@ -60,4 +75,4 @@ across real-world variability in cycle patterns and user needs:
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\item To compare prediction performance across regular and irregular cycles to assess how cycle variability affects feasibility.
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\item To evaluate model outputs in the context of practical use cases,
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such as contraception and natural family planning, using task-specific evaluation criteria.
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\end{itemize}
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\end{itemize}
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